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Chromosomal Abnormalities Origin

Chromosome abnormalities can be of two categories: numerical or structural. Numerical chromosomal abnormalities can originate at mitosis or meiosis. Some times non-disjunction of homologous chromosomes in meiosis and failure of centromere division in mitosis lead to abnormal number of chromosomal distribution in daughter cells. For example: - Down’s syndrome. Structural chromosomal abnormalities can occur during crossing over during meiosis etc. Environment and Maternal age can lead to abnormalities in chromosomes. Many children with a chromosomal abnormality have birth defects.

 

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