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 Autosomal aneuploidy :-

 

Aneuploidy means cytogenetic abnormalities in which chromosomes are added or deleted. Autosomal aneuploidy refers to all such abnormalities that do not involve the sex chromosomes. Autosomal aneuploidies have devastating effects on the fetus and mostly end in miscarriage. Down syndrome results from nondisjunction of autosomes in which many children survive. Individuals with Down syndrome have 47 chromosomes instead of the usual 46. It is a condition of trisomy for chromosome 21, meaning that they have three copies of that chromosome. Extra copies of Autosomal chromosomes cause genetic imbalance. In Down syndrome, this results in abnormal physical development and mental retardation.

 

 

 

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